Status:
COMPLETED
Cemiplimab for Secondary Angiosarcomas
Lead Sponsor:
Radboud University Medical Center
Collaborating Sponsors:
Genzyme Europe B.V.
Conditions:
Secondary Angiosarcoma
Locally Advanced Sarcoma
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Secondary angiosarcomas are aggressive mesenchymal tumors with a poor prognosis and limited therapeutic options. Recent studies conducted in patients with cutaneous squamous-cell carcinoma provide evi...
Detailed Description
Study design: A prospective, interventional, non-randomized, multicenter, phase II clinical trial. Hypothesis: Cemiplimab is registered for the use in patients with cutaneous squamous-cell carcinoma...
Eligibility Criteria
Inclusion
- Adult patient aged ≥ 18 years.
- Signed written informed consent.
- Histologically confirmed diagnosis of progressive unresectable locally advanced or metastatic secondary angiosarcoma.
- Patients in the first line of systemic treatment unfit for chemotherapy and patients in advanced lines of systemic treatment.
- Measurable disease per RECIST 1.1 or per physical examination / daylight photography (WHO Offset Publication No. 48) as determined by the investigator.
- Tumour tissue material available (archival or recent tumour biopsy).
- WHO ECOG 0-2.
- Hepatic function:
- Total bilirubin ≤ 1.5 x ULN (if liver metastases: ≤ 3 x ULN).
- Transaminases ≤ 3 x ULN (if liver metastases: ≤ 5 x ULN).
- Patients with Gilbert's Disease and total bilirubin up to 3x ULN may be eligible after communication with and approval from the medical monitor
- Alkaline phosphatase ≤ 2.5 x ULN (if liver OR bone metastases ≤5 x ULN).
- Renal function: serum creatinine ≤ 2 x ULN or estimated CrCl \> 30 mL/min.
- Creatine phosphokinase (CPK) (also known as CK \[creatine kinase\]) elevation ≤ grade 2
- Bone marrow function:
- Hemoglobulin ≥ 9.0 g/dL.
- ANC ≥ 1.5 x 109/L.
- Platelet count ≥ 75 x 109/L.
- Expected life expectancy of at least 3 months as judged by the investigator.
Exclusion
- Ongoing or recent (within 5 years) evidence of significant autoimmune disease that required treatment with systemic immunosuppressive treatments, which may suggest risk for irAEs. The following are not exclusionary: vitiligo, childhood asthma that has resolved, type 1 Diabetes mellitus, residual hypothyroidism that required only hormone therapy, or psoriasis that does not require systematic treatment.
- Prior treatment with immune checkpoint inhibitors.
- Continuous immunosuppressive corticosteroid treatment (doses \> 10 mg prednisone daily or equivalent) within 4 weeks prior to the first dose of cemiplimab. Note: patients who require a brief course of steroids (e.g. as prophylaxis for imaging studies) are not excluded.
- Active uncontrolled infection requiring therapy, including infection with HIV, active infection with HBV or HCV.
- History of pneumonitis within the last 5 years.
- Untreated brain metastasis(es) that may be considered active.
- a. Note in clarification: Patients with previously treated brain metastases may participate provided that the lesion(s) is (are) stable (without evidence of progression for at least 6 weeks on imaging obtained in the screening period), and there is no evidence of new or enlarging brain metastases, and the patients do not require any immunosuppressive doses of systemic corticosteroids for management of brain metastasis(es) within 28 days of the first dose of cemiplimab.
- Patients with allergy or hypersensitivity to cemiplimab or to any of the excipients must be excluded. Specifically, because of the presence of trace components in cemiplimab, patients with allergy or hypersensitivity to doxycycline or tetracycline are excluded.
- History of documented allergic reactions or acute hypersensitivity reaction attributed to antibody treatments
- Patients with a history of solid organ transplant (patients with prior corneal transplants may be allowed to enroll after discussion with and approval from the medical monitor).
- Any anticancer treatment other than radiation therapy (chemotherapy, targeted systemic therapy, imiquimod, photodynamic therapy), investigational or standard of care, within 30 days of the initial administration of cemiplimab or planned to occur during the study period
- Receipt of live vaccines (including attenuated) within 30 days of first study treatment
- Prior use of PI3K-D inhibitors
- Women of childbearing potential (WOCBP)\*, or sexually active men, who are unwilling to practice highly effective contraception prior to the initial dose/start of the first treatment prior to the start of the first treatment, during the study, and for at least 6 months after the last dose.
- Breastfeeding
- Positive serum pregnancy test (a false positive pregnancy test, if demonstrated by serial measurements and negative ultrasound, will not be exclusionary, upon communication with and approval from the medical monitor)
- Any other condition that might interfere with experimental treatment and the study procedures as judged by the investigator.
Key Trial Info
Start Date :
January 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 18 2024
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT04873375
Start Date
January 1 2022
End Date
October 18 2024
Last Update
October 31 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
RadboudUMC
Nijmegen, Netherlands, 6525AG