Status:
UNKNOWN
Influence of the Intestinal Microbiota on the Clinical Course of Renal Transplantation
Lead Sponsor:
Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Conditions:
Renal Transplant
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
ACKGROUND: The development of new molecular techniques, in recent years, has increasing the knowledge of the composition and functionality of the intestinal microbiota. In the area of kidney transplan...
Detailed Description
ACKGROUND: The development of new molecular techniques, in recent years, has increasing the knowledge of the composition and functionality of the intestinal microbiota. In the area of kidney transplan...
Eligibility Criteria
Inclusion
- Recipients of deceased donor kidney transplantation over 18 years of age, able to understand the informed consent form and who have agreed to participate in the study. Only patients with low immunological risk, whose induction for kidney transplantation was performed with basiliximab will be included, regardless of the maintenance immunosuppression combination
Exclusion
- Recipients of deceased donor kidney transplant with high immunological risk (within the PATHI kidney transplant program).
- Kidney transplant recipients receiving pretransplant induction with thymoglobulin or polyclonal lymphocyte antiglobulin agents.
- Living donor kidney transplant recipients.
- Patients with a history of intestinal pathology such as: ulcerative colitis, Crohn's disease or malabsorptive syndrome or irritable colon prior to their inclusion in the kidney transplant waiting list.
- Patients with dysphagia, history of aspiration pneumonia or neutropenia prior to transplantation.
- Patients who, even if they meet the inclusion criteria, upon analysis of pretransplant stool, are found to be carriers of enterotoxigenic or potentially pathogenic strains such as Clostridioides difficile, or multiresistant bacteria (BLEE and/or carbapenemase-producing).
Key Trial Info
Start Date :
December 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04874896
Start Date
December 1 2020
End Date
September 1 2025
Last Update
September 13 2023
Active Locations (1)
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1
Hospital Ramón y Cajal
Madrid, Spain, 28034