Status:
COMPLETED
Virtual-reality for Upper Limb Rehabilitation in People With Parkinson's Disease
Lead Sponsor:
Prof. Massimo Filippi
Conditions:
Parkinson Disease
Eligibility:
All Genders
Up to 85 years
Phase:
NA
Brief Summary
The aim of this study is to assess the effect of 8-week physiotherapy training using immersive virtual reality (VR-training) compared to a physiotherapy training performed in a real setting (RS-traini...
Eligibility Criteria
Inclusion
- Inclusion criteria for PD patients:
- Diagnosis of idiopathic Parkinson's disease
- H\&Y scale ≤ 3 while on medication
- Age ≤ 85 years
- Right-handedness with the Edinburgh Handedness Inventory Quotient
- Right-side involvement according to H\&Y and Movement Disorder Society Unified Parkinson's Disease Rating Scale III (MDS-UPDRS III)
- Handwriting difficulty defined by a score greater than or equal to 1 on item II.7 of the MDS-UPDRS
- Oral and written informed consent to study participation
- Inclusion criteria for healthy controls:
- Sex-matched and age-matched with PD patients;
- Right-handed;
- Oral and written informed consent to study participation.
- Exclusion criteria for PD patients:
- Mini-Mental State Examination lower than 24;
- Visual impairments that interfere with the immersive virtual environment;
- (Other) upper limb deficits impeding handwriting;
- History of (other) systemic, neurologic, psychiatric diseases, head injury and cerebrovascular alterations visible at an MRI scan;
- Family history of neurodegenerative disorders;
- History of alcohol and/or psychotropic drug abuse;
- Contraindications for MRI;
- Denied oral and written informed consent to study participation.
- Exclusion criteria for healthy controls:
- Mini-Mental State Examination lower than 28;
- Visual impairments that interfere with the immersive virtual environment;
- History of systemic, neurologic, psychiatric diseases, head injury and cerebrovascular alterations visible at an MRI scan;
- History of alcohol and/or psychotropic drug abuse;
- Contraindications for MRI;
- Denied oral and written informed consent to study participation
Exclusion
Key Trial Info
Start Date :
May 17 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 6 2024
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT04876352
Start Date
May 17 2021
End Date
September 6 2024
Last Update
April 8 2025
Active Locations (1)
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1
IRCCS San Raffaele
Milan, Italy, 20132