Status:
UNKNOWN
Characteristics of Intestinal Microbiome in the Progression of Early COPD
Lead Sponsor:
Second Affiliated Hospital of Xi'an Jiaotong University
Collaborating Sponsors:
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
18-65 years
Brief Summary
This study is aiming at explore the characteristics of intestinal microbiome during the early progression of COPD, the correlation between the changes of intestinal microbiome and the severity and ris...
Detailed Description
1. Invite participants according to inclusion criteria and exclusion criteria and divide them into 4 groups, including healthy control (HC), high-risk COPD group (HG), early COPD group (EG), mild and ...
Eligibility Criteria
Inclusion
- ≥10 pack-years smoking history;
- Examination of pulmonary function and compatible computed tomography meeting group requirements (as shown in Groups and Interventions).
Exclusion
- Take antibiotics, probiotics, prebiotics, synbiotics and other drugs that obviously interfere with intestinal microbiome within 2 months;
- Suffer from other chronic respiratory diseases other than COPD (such as bronchial asthma, allergic rhinitis, pulmonary interstitial fibrosis, bronchiectasis, lung cancer, etc.);
- Suffer from severe intestinal diseases (such as inflammatory bowel disease, intestinal infections, colorectal cancer, etc.);
- Suffer from serious hematopoietic system diseases, and the brain, heart, liver, kidney and other important organs are damaged;
- Suffer from severe hypertension, coronary heart disease, diabetes and other chronic diseases and taking drugs for long-term maintenance;
- Suffer from active infectious diseases (hepatitis B, tuberculosis, etc.);
- Pregnant or lactating women;
- Patients with obvious anxiety, depression and other psychiatric symptoms and patients with schizophrenia.
Key Trial Info
Start Date :
May 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2022
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04876833
Start Date
May 1 2021
End Date
July 1 2022
Last Update
May 10 2021
Active Locations (1)
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1
Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China, 710000