Status:
UNKNOWN
Effects of Topical Insulin on Levels of Tear Inflammatory Mediators
Lead Sponsor:
Universiti Kebangsaan Malaysia Medical Centre
Conditions:
Dry Eye
Eligibility:
All Genders
18-50 years
Phase:
PHASE1
Brief Summary
60 samples are take to determine the effects of topical insulin on tear inflammatory mediators interleukin 1a, interleukin 6 and matrix metalloprotenase 9 in diabetics with dry eye disease.
Detailed Description
Tear samples are taken to compare the levels of inflammatory markers (IL 1a, IL6 and MMP 9) pre-and post treatment with topical insulin in normal saline compared to standard therapy and normal saline ...
Eligibility Criteria
Inclusion
- all diabetics aged 18 - 50 years of age with at least mild OSDI scores
Exclusion
- Diabetics on contact lenses
- Diabetic with history of ocular surgery in the preceding 3 months
- Post menopausal women
- Known mild dry eye with prior usage of topical therapy who are unable to discontinue
- Known case of allergic eye disease
- Sjogren's syndrome patients
- Unwilling or unable to attend 6 follow up and sampling sessions
Key Trial Info
Start Date :
October 22 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 26 2022
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04877210
Start Date
October 22 2020
End Date
January 26 2022
Last Update
May 11 2021
Active Locations (1)
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1
PPUKM
Kuala Lumpur, Malaysia