Status:
COMPLETED
Enteric Neural Precursor Cells (ENPC) in the Human Gut
Lead Sponsor:
Johns Hopkins University
Conditions:
Gastrointestinal Dysmotility
Eligibility:
All Genders
18-100 years
Brief Summary
The study aim is to acquire human tissues to (a) understand the structure and organization of the human Enteric Nervous System; (b) perform a molecular transcriptomic profile of individual cells resid...
Detailed Description
(i) To study the structure and organization of the human Enteric Nervous System by tissue clarification, immunofluorescence, and 2-photon and light-sheet microscopy. (ii) To find out the molecular si...
Eligibility Criteria
Inclusion
- English speaking patients in the age range 18 - 100.
- Patients suffering from Irritable Bowel Syndrome, Inflammatory Bowel Disease, Diabetes, Gastroparesis, will be included.
- Patients suffering from Collagen disorders such as Alport Syndrome, Ehlers-Danlos Syndrome, Goodpasture Syndrome.
- Patients suffering from plexiform neurofibromas.
- Patients with bariatric surgery.
- Patients with appendicitis.
- Patients with scleroderma.
Exclusion
- Patients suffering from HIV, Hepatitis C, and other infectious diseases that require the handling of tissues in a Bio-safety level 3 environment.
- Patients suffering from infectious enteric disorders.
- Patients without any Gastrointestinal disorders (i.e. healthy volunteers).
Key Trial Info
Start Date :
April 26 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 11 2023
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT04880538
Start Date
April 26 2021
End Date
September 11 2023
Last Update
March 15 2024
Active Locations (1)
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1
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States, 21224