Status:
UNKNOWN
COVID-19 Pneumonia: Pulmonary Physiology, Health-related Quality of Life and Benefit of a Rehabilitation Program
Lead Sponsor:
University Hospital, Geneva
Collaborating Sponsors:
Ligue Pulmonaire Genevoise
Conditions:
Covid19 Pneumonia
Chronic Thromboembolic Pulmonary Hypertension
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The pathophysiological processes involved in COVID-19 pneumonia are not fully understood. Specific alterations of the airways, lung parenchyma and pulmonary vascular tree could explain a severe ventil...
Detailed Description
COVID-19 is an emerging pandemic disease caused by a novel coronavirus (SARS-CoV-2) since December 2019. This condition may be associated with a severe pneumonia and an acute respiratory distress synd...
Eligibility Criteria
Inclusion
- Patients will be eligible for inclusion if they fulfil all the following criteria:
- Patients aged ≥ 18 years.
- Confirmed diagnosis of SARS-Cov-2 infection by nasal swab, other viral sample (i.e. sputum, bronchoalveolar lavage) or Chest imaging suggestive of SARS-CoV-2 pneumonia (Chest X-ray or CT-scan).
- Requirement for oxygen supplementation.
- Persistent respiratory symptoms (i.e. dyspnoea, cough) or asthenia.
- Abnormal 6MWT at 3 months (distance \< 90% predicted or desaturation ≥ 3% or Borg \>5) and/or abnormal lung function as described by the international recommendations
- Patients will be excluded if they:
- Already had existing severe and symptomatic pulmonary condition before COVID-19 pneumonia
- Are unable to execute the different tests and surveys because of cognitive or physical limitations.
- Are already included in a structured rehabilitation program
- Have comorbidities with a life expectancy of less than 12 months.
- Any relevant acute medical disorder/acute disease state judged by the investigators as likely to represent a risk for the patient to fulfil a rehabilitation program or requiring urgent investigations.
Exclusion
Key Trial Info
Start Date :
July 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2023
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04881214
Start Date
July 1 2020
End Date
June 30 2023
Last Update
September 23 2022
Active Locations (1)
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1
Hôpitaux Universitaires de Genève
Geneva, Switzerland, 1205