Status:
UNKNOWN
Oral Low Doses Tolerance INduction Study for Peanuts
Lead Sponsor:
University Hospital, Montpellier
Conditions:
Peanut Allergy
Eligibility:
All Genders
5-65 years
Brief Summary
Several protocols have been proposed in scientifis literature, for oral tolerance induction (OIT) protocols for peanuts. A meta-analysis showed that the data in the literature are rather in favor of t...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Patients evaluated at the Montpellier University Hospital, Allergy Unit ;
- Patients aged 5 years or older;
- Patients with a history of immediate reaction after consuming peanuts
- AND a positive peanut prick test;
- AND peanut positive specific serum IgE (ImmunoCAP®);
- AND a positive oral peanut challenge test OR a clinical history of anaphylaxis AND peanut-specific IgE\> 100 kUA / L (ImmunoCAP®);
- Patients who started peanut OIT between September 2018 and January 2021.
- Exclusion criteria:
- Patients in exclusion period determined by a previous study;
- Patients under legal protection, under guardianship or under curatorship;
- Possible poor therapeutic compliance to the OIT protocol;
- Active malignant neoplasia or autoimmune disease;
- Active eosinophilic esophagitis or other gastrointestinal eosinophilic disorders;
- Severe active eczema;
- Pregnancy ;
- Cardiovascular disease and use of beta blockers and / or ACE inhibitors;
- Chronic urticaria;
- Mastocytosis.
Exclusion
Key Trial Info
Start Date :
September 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2022
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT04881773
Start Date
September 1 2018
End Date
June 1 2022
Last Update
May 11 2021
Active Locations (1)
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1
Uhmontpellier
Montpellier, France, 34295