Status:
RECRUITING
Acetaminophen and AKI After Aortic Surgery
Lead Sponsor:
Gangnam Severance Hospital
Conditions:
Aortic Surgery
Eligibility:
All Genders
20-100 years
Phase:
NA
Brief Summary
Acute kidney injury is commonly accompanied major complication after aortic surgery. Cardipulmonary bypass lyses erythrocyte and induces lipid peroxidation. This increases plasma free hemoglobin, F2-...
Eligibility Criteria
Inclusion
- 1\) Patients undergoing aortic surgery with moderate hypothermic circulatory arrest.
Exclusion
- patients with chronic kidney disease or with dialysis, eGFR \< 15ml/min/1.73m2
- allergy to acetaminophen or propacetamol HCl
- history of liver cirrhosis or total bilirubin \> 2.0mg/dL
- 3\) patients taking acetaminophen or diclofenac 4) patients who cannot understand informed consent
Key Trial Info
Start Date :
October 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2024
Estimated Enrollment :
136 Patients enrolled
Trial Details
Trial ID
NCT04882202
Start Date
October 1 2021
End Date
December 30 2024
Last Update
February 7 2024
Active Locations (1)
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1
Gangnam Severance Hospital
Seoul, South Korea