Status:
COMPLETED
KIR Sequencing and Typing for Allograft in Nancy
Lead Sponsor:
Central Hospital, Nancy, France
Collaborating Sponsors:
University of Cambridge
Conditions:
Stem Cell Transplant Complications
Eligibility:
All Genders
Brief Summary
The use of haploidentical donors for aHSCT has greatly increased this past decade leading to a major paradigm shift: while finding 10/10 HLA-matched donors represented the prior difficulty for decades...
Eligibility Criteria
Inclusion
- COHORT 1 = Matched Sibling Donors couples (MSD couples) INCLUSION CRITERIA
- recipient of HSCT selected from the French national database CRYOSTEM
- adult patients (18-50 years old)
- transplanted in first remission
- receiving myeloablative conditioning without anti-thymoglobulin
- 16 couples without any sign of GVH (8 males and 8 females)
- 16 couples with aGVH without cGVH
- 9 couples with cGVH without aGVH
- 9 couples with both cGVH and aGVH. EXCLUSION CRITERIA
- insufficient DNA material after Miltenyi extraction
- COHORT 2 = Haploidentical couples INCLUSION CRITERIA
- patient undergoing a haploidentical HSCT in the Hematology Department of Nancy's University Hospital, Lorraine, France (French Minister registration number : DC-2020-4068) EXCLUSION CRITERIA
- insufficient DNA material after Miltenyi extraction (7 MSD couples)
Exclusion
Key Trial Info
Start Date :
March 23 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 25 2019
Estimated Enrollment :
156 Patients enrolled
Trial Details
Trial ID
NCT04882605
Start Date
March 23 2015
End Date
July 25 2019
Last Update
May 12 2021
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