Status:
COMPLETED
Effects of Aerobic Exercise on Lean Non-alcoholic Fatty Liver Disease (NAFLD)
Lead Sponsor:
The First Affiliated Hospital with Nanjing Medical University
Collaborating Sponsors:
Nanjing Medical University
Conditions:
Non-alcoholic Fatty Liver Disease
Eligibility:
All Genders
30-55 years
Phase:
NA
Brief Summary
NAFLD is increasingly being identified in lean individuals, especially in Chinese population. Among the NAFLD patients, the lean NAFLD accounts for 15.9%-23.0%. Previous studies showed that the lean N...
Detailed Description
The whole study is divided into four phases: recruitment phase, training phase (1 month, aim to gradually adapt patients to the target exercise intensity), implementation phase (3 months), and follow-...
Eligibility Criteria
Inclusion
- 1\. Subjects with NAFLD determined by MRI-PDFF (liver fat\>5%).
- 2\. Subjects with BMI\<23 kg/m2.
- 3\. Subjects with inactive exercise before.
- 4\. Subjects with basic abilities of understanding, communication and writing.
Exclusion
- 1\. Regular drinkers (consumed more than an average of 140 grams of ethanol per week in men and 70 grams in women during the past twelve months).
- 2\. Complicated with other liver diseases (i.e. acute or chronic viral hepatitis, liver cancer, liver cirrhosis, drug-induced liver diseases, and autoimmune hepatitis).
- 3\. Subjects with abnormal liver function (i.e. more than 3 times the upper limit of normal alanine aminotransferase and aspartate aminotransferase).
- 4\. Complicated with severe cardiovascular disease \[i.e. myocardial infarction, arrhythmia, heart failure (New York Heart Association III or IV), uncontrolled hypertension (i.e. systolic blood pressure \>180 mmHg, and/or diastolic blood pressure \>100 mmHg)\].
- 5\. Complicated with severe kidney disease or severe renal insufficiency or tumour.
- 6\. Currently pregnant or planning to be pregnant or breast feeding women.
- 7\. Participating in weight loss programs/exercise programs currently or during the past three months.
- 8\. Having any medical condition that would affect metabolism or limit exercise (i.e. diabetes, known hyperthyroidism or hypothyroidism).
- 9\. Having a medical condition that would limit exercise participation or alter heart rate during exercise or taking medication that would affect metabolism or weight loss (i.e. glucocorticoids, antithyroid drugs, hypoglycemic drugs, antihypertensive drugs).
- 10\. Having been doing regular physical exercise for the past three months (i.e. 3 times/week, \>30 min/time).
- 11\. Subjects with poor adherence.
Key Trial Info
Start Date :
May 14 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 30 2022
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04882644
Start Date
May 14 2021
End Date
September 30 2022
Last Update
September 20 2024
Active Locations (1)
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1
The First Affiliated Hospital with Nanjing Medical University
Nanjing, China, China, 210029