Status:
UNKNOWN
The Value of FeNO in Predicting Airway Eosinophilic Inflammation
Lead Sponsor:
The First Affiliated Hospital of Guangzhou Medical University
Collaborating Sponsors:
Nanfang Hospital, Southern Medical University
Guangdong Provincial Hospital of Traditional Chinese Medicine
Conditions:
Biomarkers
Airway Inflammation
Eligibility:
All Genders
18-70 years
Brief Summary
To investigate and compare the value of FeNO, blood Eos, serum TIgE in predicting the airway eosinophilic inflammationin chronic cough, asthma and COPD.
Detailed Description
Cough is the most common complaint in the respiratory department, while asthma and chronic obstructive pulmonary disease(COPD) are two major respiratory disease that seriously endanger human health. T...
Eligibility Criteria
Inclusion
- Candidates voluntarily participate in and abide by the relevant regulations of the study, can cooperate with corresponding inspections, follow the follow-up plan, and voluntarily sign written informed consent.
- Patients with chronic cough
- Coughing lasting ≥ 8 weeks,
- There is no obvious abnormality in the chest X-ray
- No clear history of upper respiratory tract infection in the past 4 weeks,
- Newly diagnosed or untreated in the last 4 weeks
- Non-smokers.
- Patients with Asthma
- For newly diagnosed and previously diagnosed asthma patients, the diagnosis criteria for asthma:
- Including various disease severity (mild, moderate, severe), various disease states (chronic duration, acute exacerbation period).
- Non-smokers.
- Patients with COPD 1) Including patients in stable phase and acute exacerbation phase.
Exclusion
- Diagnose patients with ACO;
- Those who cannot cooperate with the completion of research-related test, follow-ups and other reasons cannot cooperate with the progress of the research;
- Combined with serious diseases of other systems (such as cardiovascular, metabolic, immune, neurological, etc.). With other diseases of the lung, including bronchiectasis.
Key Trial Info
Start Date :
May 25 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 30 2022
Estimated Enrollment :
2052 Patients enrolled
Trial Details
Trial ID
NCT04885738
Start Date
May 25 2021
End Date
May 30 2022
Last Update
May 13 2021
Active Locations (1)
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1
Guangzhou Institute of Respiratory health
Guangzhou, Guangdong, China, 510120