Status:
UNKNOWN
Vestibular Precision: Physiology & Pathophysiology
Lead Sponsor:
Massachusetts Eye and Ear Infirmary
Conditions:
Vestibular Schwannoma
Inner Ear Disease
Eligibility:
All Genders
8-80 years
Phase:
NA
Brief Summary
This project will investigate the role of noise in the vestibular system, and in particular its effects on the variability (precision) of vestibular-mediated behaviors. The investigators will study ve...
Detailed Description
The goal of this study is to investigate vestibular precision by quantifying the variability in behavioral responses that result from the neural noise inherent to the peripheral and central vestibular...
Eligibility Criteria
Inclusion
- Normal subjects:
- normal vestibular-oculomotor exams
- normal low-frequency standard rotational testing
- normal hearing
- Vestibular Schwannoma:
- existence of unilateral vestibular schwannoma (pre \& post surgical resection)
- must have sub-occipital surgical approach with complete sectioning of the vestibular nerve
- rotational testing to assess pre-surgical vestibular function
- audiogram
- brain MRI consistent with vestibular schwannoma
- audiography in each ear
Exclusion
- Normal subjects
- history of otologic or neurologic disease
- on vestibular suppressant medication (benzodiazepine, antihistamine, anticholinergic)
- Vestibular Schwannoma
- other otologic disease (other than presbycusis) or any neurologic disease (other than migraine)
- on vestibular suppressant medication (benzodiazepine, antihistamine, anticholinergic)
Key Trial Info
Start Date :
July 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2025
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT04890132
Start Date
July 1 2020
End Date
June 30 2025
Last Update
March 16 2023
Active Locations (1)
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1
Massachusetts Eye and Ear Infirmary
Boston, Massachusetts, United States, 02114