Status:
COMPLETED
Curcuminoids and Contrast-induced Acute Kidney Injury
Lead Sponsor:
Bangkok Metropolitan Administration Medical College and Vajira Hospital
Conditions:
Acute Kidney Injury
Contrast Media Toxicity
Eligibility:
All Genders
18-80 years
Phase:
EARLY_PHASE1
Brief Summary
The objective of this study was to evaluate the role of curcuminoids in the prevention of CI-AKI in CKD patients.The result of the study was prophylactic administration with curcuminoids in addition t...
Detailed Description
This study was a single-center, prospective, double-blinded, randomized placebo-controlled trial in CKD patients undergoing elective coronary angiography (CAG) at Vajira hospital from October 2018 to ...
Eligibility Criteria
Inclusion
- All the patients undergoing elective CAG at Vajira hospital from October 2018 to March 2019 were included in the study
- older than 18 years old
- stable eGFR 15-60 mL/min/1.73m2 in last 3 months.
Exclusion
- dialysis-dependent
- post-kidney transplantation
- acute heart failure or critically ill
- history of contrast or turmeric allergy
- increasing of alanine aminotransferase (ALT) or alkaline phosphatase (ALP) more than three times of normal upper limits or post-cholecystectomy
- history of AKI (as evidence by sCr change ≥ 0.3 mg/dL) within 14 days before the study - using medication included NSAIDs, warfarin, immunosuppression, N-acetyl cysteine, ascorbic acid or contrast agents within 14 days before the study
- pregnancy or lactation o
- denied consent .
Key Trial Info
Start Date :
October 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 31 2019
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT04890704
Start Date
October 1 2018
End Date
May 31 2019
Last Update
May 18 2021
Active Locations (1)
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1
Navamindradhiraj University
Bangkok, Thailand, 10300