Status:
UNKNOWN
Effect of Intraoperative Sedation on PND in Elderly Patients
Lead Sponsor:
Hebei Medical University Third Hospital
Conditions:
Elderly
Anesthesia
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
The aim of this study was to identify the effects of different depths of sedation and choices of sedative drugs on perioperative neurocognitive disorders in the elderly patients receiving hip surgery ...
Detailed Description
PND is a complication of the central nervous system after anesthesia and surgery which is considered to be a common complication in elderly patients. Age is an independent risk factor for the occurren...
Eligibility Criteria
Inclusion
- Acquisition of informed consent,
- Patients with hip fracture surgery under spinal anesthesia,
- Grade I to III based on American Society of Anesthesiologists ASA classification,
- Age ≥65.
Exclusion
- There was a history of cardiovascular and cerebrovascular adverse events in the past six months, including myocardial infarction, angina pectoris, severe arrhythmia, stroke or transient ischemic attack (TIA)
- Heart failure (NYHA III / IV and / or LVEF \< 30%)
- Bradycardia
- Respiratory failure (need oxygen)
- Glasgow Coma Scale ≤ 14 points
- Severe hepatic and renal insufficiency (child Pugh grade B or C)
- Preoperative cognitive impairment or sedative drugs (benzodiazepines, etc.).
- Adverse reactions such as allergy to dexmedetomidine or / or propofol
- Preoperative bilateral hip fracture or other trauma need simultaneous operation
- Contraindications of spinal anesthesia
Key Trial Info
Start Date :
July 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2022
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT04891458
Start Date
July 1 2021
End Date
July 31 2022
Last Update
May 18 2021
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