Status:
UNKNOWN
Hemodynamic Optimization of Cerebral Perfusion After Endovascular Therapy in Patients With Acute Ischemic Stroke
Lead Sponsor:
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Conditions:
Acute Ischemic Stroke
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Mechanical thrombectomy is a very effective treatment in patients who have suffered an acute ischemic stroke associated with intracranial large vessel occlusion. However, less than half of the patient...
Eligibility Criteria
Inclusion
- Patients with acute ischemic stroke and large intracranial vessel occlusion within 24 hours after the onset of symptoms in whom mechanical thrombectomy has been performed.
- Successful recanalization, defined as a TICI score of 2b, 2c, or 3.
- Previous score on the modified Rankin scale (mRS) of 0, 1, or 2.
- The patient or her legal representative gives informed written or verbal consent
Exclusion
- ASPECTS score \<6
- Vertebral, basilar, A2, P2 and M3-4 occlusion
- History of intracerebral hemorrhage
- Pregnant or breastfeeding patient
- Patient with congestive heart failure or recent/unstable coronary artery disease (\<3 months)
- Dissection of aorta, cervical or cerebral or unruptured aortic / cerebral aneurysm or known arteriovenous malformation
- Any bleeding visible on baseline CT
- History of ventricular arrhythmias
- Use of MAO inhibitors
- Inclusion in other clinical trials.
Key Trial Info
Start Date :
June 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2024
Estimated Enrollment :
814 Patients enrolled
Trial Details
Trial ID
NCT04892511
Start Date
June 1 2021
End Date
September 30 2024
Last Update
March 16 2023
Active Locations (1)
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1
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain