Status:
UNKNOWN
Prediction of the Development of Heart Failure With Preserved Ejection Fraction
Lead Sponsor:
Heart Center Leipzig - University Hospital
Conditions:
Heart Failure With Preserved Ejection Fraction
Eligibility:
All Genders
18+ years
Brief Summary
The ultimate goal of the PREDICT-HFpEF study is to identify and unravel predictors for the development of heart failure with preserved ejection fraction (HFpEF) in a cohort at increased cardiovascular...
Detailed Description
Heart failure with preserved ejection fraction (HFpEF) is associated with severe morbidtiy and mortality. Yet, little is known about factors leading to the development of HFpEF investigated in a longi...
Eligibility Criteria
Inclusion
- At timepoint of inclusion in the LIFE-Heart study normal left ventricular ejection fraction (≥ 50%)
- At timepoint of inclusion in the LIFE-Heart study normal NT-proBNP (\< 125 ng/l)
Exclusion
- At timepoint of inclusion in the LIFE-Heart study acute coronary syndrom
- Troponine elevation above 14 pg/ml as well as coronary intervention, or isolated troponine elevation above 50 pg/ml in the absence of a coronary intervention
- No troponine elevation but coronary intervention
- Creatine kinase \> 0.41 µmol/l\*s and Creatine kinase to Creatine kinase-MB ration \>6% or Creatine kinase-MB \> 0.82 µmol/l\*s
- At timepoint of inclusion in the LIFE-Heart study missing data on left ventricular ejection fraction
- At timepoint of inclusion in the LIFE-Heart study missing NT-proBNP measurement
- At timepoint of inclusion in the LIFE-Heart study missing data on echocardiographic diastolic function and structural alterations of the left ventricle
- At timepoint of inclusion in the LIFE-Heart study relevant valvular heart disease (including relevant aortic stenosis, mitral- and/or tricuspid regurgitation, congenital heart disease, mitral stenosis)
Key Trial Info
Start Date :
December 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2022
Estimated Enrollment :
800 Patients enrolled
Trial Details
Trial ID
NCT04894968
Start Date
December 1 2018
End Date
November 1 2022
Last Update
March 17 2022
Active Locations (1)
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1
Heart Center Leipzig at Leipzig University
Leipzig, Saxony, Germany, 04289