Status:
RECRUITING
Phenylalanine-free Diet for Patients With Secondary Hyperphenylalaninemia in ICU
Lead Sponsor:
Chang Gung Memorial Hospital
Conditions:
Non-Phenylketonuric Hyperphenylalaninemia
Eligibility:
All Genders
20+ years
Phase:
NA
Brief Summary
Hyperphenylalaninemia is not only present in patients with congenital phenylketonuria. In adults with critical illness, hyperphenylalaninemia is noted in some patients and is associated with high mort...
Detailed Description
Background: Patients in the intensive care unit often suffer from problems such as high metabolic rate and high tissue breakdown rate under the severe stress of critical diseases. Phenylalanine is an...
Eligibility Criteria
Inclusion
- had Acute Physiology And Chronic Health Evaluation (APACHE II) scores of ≥15;
- were expected to stay in the ICU \>48 hours;
- patients with baseline PHE levels of ≥95 uM;
- were over 20 years old.
Exclusion
- patients with comorbid disorders other than the main cause for admission that might compromise their survival within three months, such as terminal stage cancer;
- patients with expected survival \<3 days.
Key Trial Info
Start Date :
July 30 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04896281
Start Date
July 30 2021
End Date
December 31 2024
Last Update
March 18 2024
Active Locations (1)
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1
Chang Gung Memorial Hospital
Keelung, Taiwan, 402