Status:
COMPLETED
Neuroimaging Mechanisms by Which Memory and Glucocorticoids Promote Risky Drinking
Lead Sponsor:
Yale University
Conditions:
Alcohol Drinking
Drinking Behavior
Eligibility:
All Genders
21-45 years
Phase:
EARLY_PHASE1
Brief Summary
The purpose of this study is to determine whether hydrocortisone biases formation of alcohol-related memories to potentiate drinking.
Detailed Description
This study aims to 1) Characterize the effect of elevated glucocorticoids during encoding on long-term memory for alcohol-related information; 2) Identify the neural mechanisms by which glucocorticoid...
Eligibility Criteria
Inclusion
- Able to read and write English
- BMI 18-35
- Beer drinking
Exclusion
- Meet current criteria for any substance use disorder, excluding caffeine
- Current significant medical conditions or psychiatric symptoms requiring medication
- Current use of medications/drugs that interfere with the HPA axis response
- Peri and post-menopausal women, pregnant or lactating women, and those with hysterectomies
- Metal in body (for MRI safety)
- Systemic fungal infections (contraindication for hydrocortisone)
- Known hypersensitivity to components of hydrocortisone tablets (hydrocortisone, calcium stearate, corn starch, lactose, mineral oil, sorbic acid, sucrose)
Key Trial Info
Start Date :
May 12 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 15 2022
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT04896489
Start Date
May 12 2021
End Date
March 15 2022
Last Update
June 2 2022
Active Locations (1)
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1
Yale University
New Haven, Connecticut, United States, 06511