Status:
COMPLETED
LEAP2 Kinetics in Healthy Individuals
Lead Sponsor:
University Hospital, Gentofte, Copenhagen
Conditions:
Obesity
Eligibility:
MALE
18-25 years
Phase:
EARLY_PHASE1
Brief Summary
The study aims to investigate the kinetics of the naturally occurring peptide liver-enriched antimicrobial peptide 2 (LEAP-2) in healthy volunteers. The overall objective is to investigate the physiol...
Detailed Description
In a recent study, the molecular phenotype of enteroendocrine cells in the small intestine before and after Roux-en-Y Gastric Bypass (RYGB) surgery in obese individuals was examined. Enteroendocrine c...
Eligibility Criteria
Inclusion
- Caucasian men
- Age between 18 and 25 years
- Body mass index between 20-35 kg/m2
- Informed consent
Exclusion
- Anaemia (haemoglobin below normal range)
- Alanine aminotransferase (ALAT) and/or aspartate aminotransferase (ASAT) \>2 times normal values) or history of hepatobiliary and/or gastrointestinal disorder(s)
- Nephropathy (serum creatinine above normal range and/or albuminuria)
- Allergy or intolerance to ingredients included in the standardised meals
- First-degree relatives with diabetes and/or glycated haemoglobin (HbA1c) \>48 mmol/mol
- Regular tobacco smoking or use of other nicotine-containing products
- Any ongoing medication that the investigator evaluates would interfere with trial participation.
- Any physical or psychological condition that the investigator evaluates would interfere with trial participation including any acute or chronic illnesses
Key Trial Info
Start Date :
May 24 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 25 2021
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT04897984
Start Date
May 24 2021
End Date
June 25 2021
Last Update
September 28 2021
Active Locations (1)
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1
Center for Clinical Metabolic Research
Hellerup, Denmark, 2900