Status:
RECRUITING
POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium
Lead Sponsor:
University Hospitals Coventry and Warwickshire NHS Trust
Collaborating Sponsors:
Coventry University
Conditions:
Heart Failure
Fatigue; Muscle, Heart
Eligibility:
All Genders
18-85 years
Brief Summary
To gain a comprehensive understanding of the biomechanical behaviour of human heart to explore the concept of myocardial fatigue in response to a temporal range of preload, afterload and drug-induced ...
Detailed Description
A continuum of pathological states from fatigue, injury to damage of the myocardium has been proposed which complements the continuous spectrum of HF and reconciles the seemingly disparate plethora of...
Eligibility Criteria
Inclusion
- All adult patients between 18 to 85-years old undergoing open-heart surgery who can undergo the consent process for the study
- Healthy donor hearts that are deemed non-transplantable and consent received from a legal representative
Exclusion
- This criterion is kept to a minimum since the availability of human myocardial samples is finite and dependent on the limited number of patients undergoing cardiac surgery annually within the local hospital.
- Patients who do not have the mental capacity to undergo the consent process
- For the safety of researchers, patients with evidence of ongoing blood-borne infections such as HIV, or a recent positive test for COVID-19 (within 10 days of last PCR test).
Key Trial Info
Start Date :
August 3 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 30 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04899635
Start Date
August 3 2021
End Date
April 30 2025
Last Update
June 18 2024
Active Locations (1)
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1
University Hospitals Coventry and Warwickshire
Coventry, United Kingdom, CV22DX