Status:
ACTIVE_NOT_RECRUITING
The Impact of Energy Intake and Short-term Disuse on Muscle Protein Synthesis Rates and Skeletal Muscle Mass in Middle-aged Adults.
Lead Sponsor:
University of Exeter
Conditions:
Muscle Atrophy
Aging
Eligibility:
All Genders
35-65 years
Phase:
NA
Brief Summary
In healthy middle-aged men and women, what is the effect of dietary energy restriction and energy surplus on daily muscle protein synthesis rates and muscle morphology, compared to energy balance, dur...
Detailed Description
Background Age related muscle tissue loss, which is associated with a number of negative health outcomes is partially caused by blunted muscle protein synthesis rates (MPS) in response to food ingesti...
Eligibility Criteria
Inclusion
- Age 35-65 Healthy Non-smoker Recreationally active
Exclusion
- Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes) Any diagnosed cardiovascular disease or hypertension Elevated blood pressure at the time of screening. (An average systolic blood pressure reading of ≥150mmHg over two or more measurements and an average diastolic blood pressure of ≥90mmHg over two or more measurements.) Chronic use of diabetic medication. A personal or family history of epilepsy, seizures or schizophrenia. Allergic to mycoprotein / Quorn, penicillin, or cow's milk. Any musculoskeletal injury that may impair their use of crutches. Any diagnosed severe digestive illness. Any diagnosed severe autoimmune disease. Any diagnosed cancer. Any metal fragments in the eyes, a pacemaker, or metal implants in the body that preclude MRI scanning.
Key Trial Info
Start Date :
November 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2025
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT04900701
Start Date
November 1 2021
End Date
June 1 2025
Last Update
January 16 2025
Active Locations (2)
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1
Sport & Health Sciences University of Exeter
Exeter, Devon, United Kingdom, EX1 2LU
2
University of Exeter, Sports & Health Sciences, College of Life & Environmental Sciences
Exeter, Devon, United Kingdom, EX1 2LU