Status:
COMPLETED
Vonoprazan in Helicobacter Pylori Treatment an RCT
Lead Sponsor:
Dow University of Health Sciences
Conditions:
Helicobacter Pylori Infection
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
RCT for comparison of Standard Triple therapy (Omeprazole+Amoxil+Clarithromycin) for H Pylori erradication with Vonoprazan+Amoxil dual therapy.
Detailed Description
OBJECTIVE To compare the efficacy of Vonoprazan based dual treatment versus PPI based treatment for the eradication of Helicobacter pylori infection. OPERATIONAL DEFINITION Helicobacter Pylori infec...
Eligibility Criteria
Inclusion
- Helicobacter Pylori Positive by any one of following:
- Histopathology by Giemsa Stain Stool Antigen
Exclusion
- • Previous surgery of the stomach such as partial gastrectomy.
- Allergy to any of the antibiotics used in the study.
- Intake of antibiotics, PPIs, corticosteroids, or nonsteroidal anti-inflammatory drugs within the last 2 weeks.
- Pregnant or lactating females.
- Alcohol abuse or drug addiction.
- Severe neurological or psychiatric disorder.
Key Trial Info
Start Date :
June 21 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 16 2021
Estimated Enrollment :
179 Patients enrolled
Trial Details
Trial ID
NCT04901663
Start Date
June 21 2021
End Date
August 16 2021
Last Update
August 18 2021
Active Locations (1)
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1
Dr Ruth KM Pfau Civil Hospital Karachi
Karachi, Sindh, Pakistan, 74400