Status:
RECRUITING
Cognitive and Affective Mechanisms Underlying an Olfactory Approach to Modify Cigarette Craving
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Center for Complementary and Integrative Health (NCCIH)
Conditions:
Craving
Eligibility:
All Genders
18-49 years
Phase:
NA
Brief Summary
The proposed study uses fMRI and behavioral measures in and outside the laboratory to investigate the neurobehavioral mechanisms underlying the impact of pleasant olfactory cues (OCs) on cigarette cra...
Detailed Description
The investigators aim to conduct a comprehensive analysis of craving and to test the impact of pleasant olfactory cues (OCs) on craving relief. Towards these aims, this study will integrate four sourc...
Eligibility Criteria
Inclusion
- Aged 18-49
- Right-handed
- Fluent in English
- Intact sense of smell
- Pass an MRI safety screening and along these lines will need to be 250lbs or less to safely enter the MRI
- No drug dependence outside of nicotine or caffeine
- Must fit into one of two categories of smokers, daily or nondaily, as confirmed by verbal self-report and a baseline CO reading; Daily smokers: must smoke 10-30 cigarettes per day for at least 12 months, Nondaily smokers: must smoke for 1-14 days of the last 30 days with no more than 20 cigarettes a day
- Need to have access to a working smartphone to complete the ecological momentary assessment portion of the study
Exclusion
- Medical conditions that contraindicate nicotine use
- Not fluent in English
- Illiterate
- Current neurological or psychotic disorders
- Current psychoactive drug use
- MRI contraindications such as stroke history, pregnancy, metal in the body, history of aneurysms, or serious head injury
- Individuals will also be excluded if they report any allergies to the odors used in our study.
- Baseline CO readings will need to be consistent with our criteria for daily and nondaily smokers for participants to be considered eligible. Specifically, we plan to rule out extremely heavy smokers (nondeprived CO \> 55, for whom the smoking abstinence requirement may be too extreme to allow a sensitive test of our OC manipulation) and daily smokers with a nondeprived CO reading \<10 PPM as this would raise concerns that they do smoke enough to be classified as a daily smoker.
Key Trial Info
Start Date :
December 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT04902469
Start Date
December 1 2021
End Date
June 1 2026
Last Update
July 3 2025
Active Locations (1)
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1
The University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15260