Status:
WITHDRAWN
Comparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Inducing Latent Left Ventricular Outflow Obstruction in Hypertrophic Cardiomyopathy
Lead Sponsor:
Mayo Clinic
Conditions:
Hypertrophic Cardiomyopathy
Hypertrophic Obstructive Cardiomyopathy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to assess the effectiveness of squat-to-stand maneuver in eliciting left ventricular outflow gradients in patients with Hypertrophic Cardiomyopathy (HCM) compared to Valsa...
Detailed Description
Left ventricular hypertrophy and abnormal ventricular configuration result in dynamic left ventricular outflow obstruction in \~75% of HCM patients, which is associated with increased cardiac morbidit...
Eligibility Criteria
Inclusion
- Adults ≥ 18 y/o referred for an outpatient echocardiogram.
- Clinical diagnosis of Hypertrophic Cardiomyopathy (HCM).
- Both amyl nitrite inhalation and squat-to-stand maneuver performed during echocardiogram.
Exclusion
- Patients \< 18 at the time of echocardiogram.
- Studies without documented provocative maneuvers.
- Patients with resting obstruction (MIG \> 50 mmHg).
- Patients unable to undergo the squat-to-stand as protocolled based because of physical limitations.
- Patient with contraindications to amyl nitrite administration.
Key Trial Info
Start Date :
November 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2022
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04905173
Start Date
November 1 2021
End Date
May 1 2022
Last Update
January 11 2022
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