Status:
COMPLETED
NR Supplementation and Exercise
Lead Sponsor:
Maastricht University Medical Center
Conditions:
Overweight and Obesity
Aging
Eligibility:
All Genders
65-80 years
Phase:
NA
Brief Summary
The number of age-related chronic diseases (like obesity, type 2 diabetes and cardiovascular diseases) is increasing rapidly worldwide, reaching pandemic proportions. These age-related chronic disease...
Detailed Description
Rationale: The number of age-related chronic diseases (like obesity, type 2 diabetes and cardiovascular diseases) is increasing rapidly worldwide, reaching pandemic proportions. These age-related chro...
Eligibility Criteria
Inclusion
- Participants are able to provide signed and dated written informed consent prior to any study specific procedures
- Aged ≥ 65 and ≤ 80 years
- Body mass index (BMI) 25 - 35 kg/m2
- Stable dietary habits (no weight loss or gain \> 5 kg in the past 3 months)
- No signs of active cardiovascular disease, liver or kidney malfunction
Exclusion
- Type 2 diabetes
- Patients with congestive heart failure and and/or severe renal and or liver insufficiency
- Uncontrolled hypertension
- Any contra-indication for MRI scanning
- Alcohol consumption of \>3 servings per day for man and \>2 servings per day for woman
- Smoking
- Unstable body weight (weight gain or loss \> 5kg in the last 3 months)
- Engagement in structured exercise activities \> 2 hours a week
- Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the Investigator which would possibly hamper our study results
- Medication use known to hamper subject's safety during the study procedures
- Subjects who do not want to be informed about unexpected medical findings
- Use of food supplements containing NR or Resveratrol (similar working mechanisms)
Key Trial Info
Start Date :
August 10 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 7 2022
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04907110
Start Date
August 10 2021
End Date
December 7 2022
Last Update
February 10 2023
Active Locations (1)
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1
Maastricht University
Maastricht, Netherlands, 6229 ER