Status:
RECRUITING
Spectroscopic MRI Guided Proton Therapy in Assessing Metabolic Change in Pediatric Patients With Brain Tumors
Lead Sponsor:
Emory University
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Malignant Brain Glioma
Eligibility:
All Genders
Up to 21 years
Phase:
NA
Brief Summary
This trial studies how well spectroscopic magnetic resonance imaging (MRI) guided proton therapy works in assessing metabolic change in pediatric patients with brain tumors. The non-invasive imaging, ...
Detailed Description
PRIMARY OBJECTIVES: I. To obtain spectroscopic (s)MRI data from pediatric high grade glioma (HGG) patients before receiving standard of care radiation therapy (RT) and correlate baseline Cho/NAA rati...
Eligibility Criteria
Inclusion
- Pathologically diagnosed high-grade glioma (World Health Organization \[WHO\] grade 3-4). Patients with a radiographically diagnosed high-grade glioma may enroll prior to pathologic confirmation, but would be removed from study if pathology did not confirm the diagnosis of high-grade glioma.
- Primary tumor located within the supratentorial brain.
- Recommended to receive definitive radiation therapy.
- Able to receive MRI scans.
- Both males and females, and members of all races and ethnic groups are eligible for this trial.
Exclusion
- Patients with pacemakers, non-titanium aneurysm clips, neurostimulators, cochlear implants, non-titanium metal in ocular structures, or other incompatible implants which makes MRI safety an issue are excluded.
- Patients that have any significant medical illnesses that in the investigator's opinion cannot be adequately tolerate MRI scan are excluded.
- Pathology demonstrated low-grade glioma or other benign or non-invasive brain tumor.
Key Trial Info
Start Date :
December 20 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 13 2030
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT04908709
Start Date
December 20 2018
End Date
October 13 2030
Last Update
November 8 2024
Active Locations (3)
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1
Emory Proton Therapy Center
Atlanta, Georgia, United States, 30308
2
Children's Healthcare of Atlanta - Scottish Rite
Atlanta, Georgia, United States, 30322
3
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, United States, 30322