Status:
COMPLETED
rTMS in Wilson Disease Dysarthria
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Wilson Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Wilson disease is a hereditary hepatic and neurological disease associated with copper accumulation. Neurological symptoms are of extra-pyramidal, cerebellar and dystonic origin. Dysarthria is one of ...
Detailed Description
A consecutive series of Wilson disease patients with dystonic hyperkinetic dysarthria will be prospectively recruited. Patients will receive 3 days apart to two rTMS sessions. rTMS procedures will b...
Eligibility Criteria
Inclusion
- Conseting adult patients with social insurance
- Wilson disease with dystonic hyperkinetic dysarthria
- Stable pharmacological therapy n the last 6 monts
- Brain MRI in the previous 6 months, without additional brain lesion
- Patients that did not receive botulinium toxin in the previous 4 months
Exclusion
- Incapacitated adult
- Previous mdedical history of epilepsia
- Pregnancy or breastfeeding
- Brain lesion outside basal ganglia on brain MRI
- Patient consider by the investigator not able to sustain an 30 minutes rTMS session without moving
- Vocal chord lesion
- Previous history of laryngeal surgery
- rTMS contra indication
Key Trial Info
Start Date :
January 23 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 12 2024
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT04910581
Start Date
January 23 2023
End Date
January 12 2024
Last Update
February 28 2024
Active Locations (2)
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1
Service de Physiologie Clinique-Explorations Fonctionnelles, AP-HP, Hôpital Lariboisière
Paris, France, 75010
2
Service de Neurologie, Hopital Fondation Adolphe de Rothschild
Paris, France, 75019