Status:
RECRUITING
PEEP in Patients With Acute Respiratory Failure
Lead Sponsor:
Jesus Villar
Conditions:
Acute Respiratory Failure With Hypoxia
Eligibility:
All Genders
18+ years
Brief Summary
Positive end-expiratory pressure (PEEP) has become an essential component of the care of critically ill patients who require ventilatory support. In 1975, several investigators published the effects o...
Detailed Description
With the application of PEEP, the baseline end-expiratory pressure in mechanically ventilated patients is elevated above atmospheric pressure. PEEP is applied generally to improve oxygenation, which i...
Eligibility Criteria
Inclusion
- Intubated patients requiring MV for \>24 h
- Age \>18 years
- Acute hypoxemic respiratory failure, defined as a PaO2/FiO2 \<300 with an FiO2 ≥0.3 and PEEP≥5 cmH2O.
- ARF caused by pulmonary insults.
Exclusion
- ARF from non-pulmonary origin.
- Contraindications from high PEEP (severe head trauma or severe chest trauma).
- Patients that cannot maintained supine position.
- Uncorrected hypovolemia
- Hemodynamic instability
Key Trial Info
Start Date :
June 10 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT04912960
Start Date
June 10 2021
End Date
December 31 2025
Last Update
April 20 2025
Active Locations (3)
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1
Hospital Universitario Dr. Negrin
Las Palmas de Gran Canaria, Las Palmas, Spain, 35019
2
Hospital Clinic
Barcelona, Spain
3
Hospital Universitario La Princesa
Madrid, Spain