Status:
UNKNOWN
CT and MRI in Prediction of Response in Patients With Gastric Cancer Following Neoadjuvant Chemotherapy and/or Immunotherapy
Lead Sponsor:
The First Hospital of Jilin University
Conditions:
Gastric Cancer
Magnetic Resonance Imaging
Eligibility:
All Genders
18-80 years
Brief Summary
This is a prospective and observational clinical study for seeking out a better way to predict the pathologic complete response (pCR) in patients with advanced gastric cancer (AGC) based on the post-n...
Detailed Description
With the gradual development of neoadjuvant immunotherapy and/or chemotherapy in the clinic, the pCR has become more and more accessible in the AGC. Preoperative accurate prediction of pCR is of great...
Eligibility Criteria
Inclusion
- Age 18 Years to 80 Years
- Consecutive patients with preoperative pathologically confirmed AGC by endoscopy and preoperative imaging data (CT/MRI) were included.
- Clinical staging Ⅱ-Ⅲ according to the UICC/AJCC 8th guideline for gastric cancer without distant metastasis.
- Suitable for pre-operative chemotherapy, immunotherapy and surgical resection
- No contraindications for CT/MRI examination.
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
- The patients participate in this study with informed consent.
Exclusion
- Patients with a history of previous chemotherapy or immunotherapy.
- The patients couldn't perform MSCT or MR scanning or artefacts affect the evaluation.
- The patients are extremely anxious and uncooperative about surgery or neoadjuvant therapy.
- The patients refuse to participate in the project.
- Pregnancy, lactation or inadequate contraception
- Pacemaker or implanted defibrillator
- Patients with a history of psychological illness or condition such as to interfere with the patient's ability to understand requirements of the study.
- Other situations considered by investigators, which not meet the inclusion criteria.
Key Trial Info
Start Date :
June 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2023
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04913896
Start Date
June 1 2021
End Date
June 1 2023
Last Update
June 4 2021
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