Status:
COMPLETED
Effects of a Probiotic on Oral Microbiota and Glycemic Control in Type 2 Diabetics; A Randomized Clinical Trial
Lead Sponsor:
Istanbul University
Conditions:
Diabetes Mellitus,Type 2
Periodontitis
Eligibility:
All Genders
30-65 years
Phase:
NA
Brief Summary
The present study evaluated clinically the effects of a probiotic on oral microbiota and glycemic control in T2 diabetic patients with periodontal disease. The study was designed as a prospective rand...
Detailed Description
Objectives: To investigate the effects of an oral probiotic use, containing 4 billion colony forming unit (CFU/g) Streptococcus Salivarius M18 strain (Dentoblis™), on the quantities of oral microbiota...
Eligibility Criteria
Inclusion
- being diagnosed with T2 diabetes with \<10% HbA1C for at least 6 months,
- 30-65 years old patients,
- high caries activity patients with Periodontal Disease Index (PDI) scores of 2, 3, 4 and 5,
- provision of written informed consent -
Exclusion
- patients regularly using probiotics,
- patients on corticosteroid, non-steroid anti-inflammatory, antibiotic or antibacterial mouthwash therapy,
- patients with multi-organ deficiency such as liver or kidney failure,
- patients with Immunodeficiency syndrome or on immunosuppressive therapy,
- patients with heart valve prosthesis or central venous catheter,
- patients undergoing chronic or acute disease therapy such as cancer, arthritis, influenza, flu,
- legal incapability or mental incapacity to give consent.
Key Trial Info
Start Date :
September 10 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 14 2018
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT04913909
Start Date
September 10 2015
End Date
March 14 2018
Last Update
June 4 2021
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