Status:
COMPLETED
Are Standard Dosing Regimens of Piperacillin-Tazobactam Suitable in Critically Ill Patients With Open Abdomen and Negative Pressure Wound Therapy? A Population Pharmacokinetic Study.
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Laparotomy
Critical Illness
Eligibility:
All Genders
18+ years
Brief Summary
For several years, open abdomen with temporary abdominal closure using Negative Pressure Therapy (OA/NPT) has become one of the leading strategies to treat or prevent intra-abdominal hypertension in c...
Eligibility Criteria
Inclusion
- Age ≥ 18
- Admitted in surgical ICU for a suspected length of stay \> 3 days
- Receiving an antimicrobial therapy by PTZ
- For an intra-abdominal infection
- Under OA/NPT during antimicrobial therapy
- With urinary and arterial catheters
Exclusion
- Severe renal failure (CLCR \< 30 ml/min) without indication for continuous renal replacement therapy (CRRT)
- Known allergy to PTZ
- Patient's refusal for participation to the research
- Patient unable to consent (dementia or severe psychiatric disorders, people under legal protection, people deprived of their liberty...)
- Pregnancy or breast-feeding
Key Trial Info
Start Date :
July 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 27 2023
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT04915872
Start Date
July 1 2021
End Date
January 27 2023
Last Update
February 27 2023
Active Locations (1)
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1
CHU de Bordeaux
Bordeaux, France