Status:
UNKNOWN
Effect of Vitamin D Oral Supplementation in Poly Csytic Ovarian Women Resistant to Clomiphene Citrate
Lead Sponsor:
rana alaaeldin aly ibrahim nasr
Collaborating Sponsors:
Ain Shams University
Conditions:
Vitamin D Deficiency
Clomiphene Allergy
Eligibility:
FEMALE
18-40 years
Phase:
PHASE1
PHASE2
Brief Summary
effect of vitamin D oral supplementation in poly csytic ovarian women resistant to clomiphene citrate
Detailed Description
Polycystic ovarian syndrome is the most common endocrine disorder . It is associated with chronic anovulation and infertility. The diagnosis is made by clinical and ancillary investigations revealing ...
Eligibility Criteria
Inclusion
- Age: 18-40 years 2- Polycystic ovarian syndrome diagnosis made according to ESHRE/ASRM criteria.
- Polycystic ovaries (either 12 or more follicles or increased ovarian volume \[\> 10 cm3
- Oligo-ovulation or anovulation
- Clinical and/or biochemical signs of hyperandrogenism (Azziz, 2006). 3- PCOS infertile women resistant to CC for 3 cycles. clomiphene citrate resistance means failure to ovulate with 3 months use of clomid at 150 mg/day for 5 days
Exclusion
- Causes of infertility other than PCOS.
- Male factor.(normal semen analysis)
- Other factors e.g. endometriosis
- Tubal factor. (normal hysterosalpingography)
- Premature ovarian failure: Day 3 FSH \> 14 mlu/ml or antimullerian hormone \<1 ng/ml.
- Normal ultrasound except for criteria of PCO
- Causes of anovulation other than PCOS.
- Patients with hyperprolactinemia
- Patients with thyroid dysfunction.
- Current or in last six months use of vit D treatment.
Key Trial Info
Start Date :
August 21 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2021
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04916925
Start Date
August 21 2021
End Date
December 1 2021
Last Update
June 8 2021
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