Status:
COMPLETED
Capsaicin to Prevent Delayed Chemotherapy Induced Nausea and Vomiting (CapCIN)
Lead Sponsor:
Christian Medical College, Vellore, India
Conditions:
Chemotherapy-induced Nausea and Vomiting
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Chemotherapy-induced nausea and vomiting (CINV) is one of the few most severe adverse effects of chemotherapy, which often panic patients undergoing cancer treatment. Though acute episodes of CINV are...
Eligibility Criteria
Inclusion
- Adult chemotherapy naïve patients of at least 18 years old
- Diagnosed with a malignant disease and scheduled for highly emetogenic chemotherapy (as defined by NCCN guidelines v1.2019)
- No concurrent radiotherapy or use of other antiemetic drugs except (dexamethasone, ondansetron/granisetron, and olanzapine)
- Normal renal and hepatic function
Exclusion
- Pregnant or breast feeding
- Contraindication for capsaicin or other medications in the study
- Has ongoing nausea and/or vomiting of other etiology
- History of anticipatory nausea and/or vomiting or has vomited/nauseated within 24 hours prior to the start of scheduled chemotherapy
- Chronic alcoholism
Key Trial Info
Start Date :
October 18 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 14 2022
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT04918069
Start Date
October 18 2019
End Date
May 14 2022
Last Update
May 20 2022
Active Locations (1)
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1
Christian Medical College
Vellore, Tamil Nadu, India, 632004