Status:
ACTIVE_NOT_RECRUITING
rTMS, Stress and Opioid Use Disorder
Lead Sponsor:
Wayne State University
Conditions:
Opioid Use Disorder
Eligibility:
All Genders
21-70 years
Phase:
NA
Brief Summary
Opioid agonist treatments are the gold standard for treating opioid use disorder (OUD). Yet, even effective treatments average only 50% six-month retention. Despite extensive research into treatment o...
Detailed Description
The Competing Neurobehavioral Decisions Systems (CNDS) model of addiction suggests that people with SUDs have altered function and connectivity in fronto-cortical executive control regions (e.g. dorso...
Eligibility Criteria
Inclusion
- Meet DSM-5 criteria for OUD;
- In methadone or buprenorphine treatment
- Age 21-70 yr;
- Right handed;
- Males and non-pregnant/non-lactating females;
- Cognitively intact (total IQ score \>80);
- Use alcohol and/or marijuana \<4 times per week; each "time" should consist of \<2 marijuana "joint" equivalent and \<4 alcoholic drinks.
Exclusion
- Acutely under the influence of any substance (except methadone or buprenorphine) during session;
- Current, regular (\>2 times/week) use of illicit drugs other than opioids (except cannabis);
- Any past 24 hour use of drugs other than opioids or nicotine;
- Urinalysis positive for pregnancy;
- Medical conditions prohibiting use of rTMS;
- Lifetime psychotic, bipolar, or potentially antisocial personality disorder;
- Untreated or uncontrolled past-year diagnosis of major depression, generalized anxiety disorder, obsessive compulsive disorder, or post traumatic stress disorder;
- Past-month SUD other than OUD or tobacco use disorder;
- Acute/unstable illness making it unsafe for participation;
- Any prohibited medications including: medications that lower seizure threshold, certain psychiatric medications, or prescription pain medications;
- Chronic head or neck pain;
- Past-month participation in a research study.
Key Trial Info
Start Date :
April 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT04920864
Start Date
April 1 2022
End Date
December 1 2026
Last Update
December 30 2025
Active Locations (1)
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1
Tolan Park Medical Building
Detroit, Michigan, United States, 48201