Status:
RECRUITING
A Combined Multidomain Intervention to Prevent Cognitive Decline Associated With Cardiovascular Risk Factors.
Lead Sponsor:
Louis Bherer
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
The Montreal Health Innovations Coordinating Center (MHICC)
Conditions:
Aging
Cardiovascular Risk Factor
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
The ACTIONcardioRisk trial is designed to investigate the effect of aerobic and progressive resistance training exercises combined with cognitive training, on neurocognitive functioning of sedentary o...
Detailed Description
The proportion of older adults is on the rise in Canada, with the fastest growth recorded among those seventy years of age or older. The prevalence of cardiovascular risk factors (CVRF) such as diabet...
Eligibility Criteria
Inclusion Criteria:
- Adult aged 60 and older,
- Normal or corrected vision and normal hearing for their age range,
- No cognitive impairment (Mini-Mental State Examination - MMSE ≥ 25),
- Inactive (< 150 min of physical activity per week).
Exclusion Criteria:
- MMSE ≤ 24 or diagnosis of dementia,
- Uncontrolled psychological / psychiatric condition within the past 6 months,
- Neurological disease,
- Severe exercise intolerance,
- Respiratory disease (e.g., asthma, COPD),
- Excessive alcohol consumption (> 15 drinks/week),
- Documented cerebral, peripheral or coronary atherosclerotic disease,
- Chronic systolic or diastolic heart failure,
- Symptomatic aortic stenosis,
- Atrial fibrillation,
- Automatic implantable defibrillator or permanent pacemaker,
- Malignant exertional arrhythmias,
- Non-cardiopulmonary limitation to exercise (e.g., arthritis).
Key Trial Info
Start Date :
September 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
159 Patients enrolled
Trial Details
Trial ID
NCT04962061
Start Date
September 1 2021
End Date
December 31 2025
Last Update
February 6 2025
Active Locations (1)
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1
Preventive medicine and physical activity centre (centre EPIC), Montreal Heart Institute
Montreal, Quebec, Canada, H1T1N6