Status:

RECRUITING

A Combined Multidomain Intervention to Prevent Cognitive Decline Associated With Cardiovascular Risk Factors.

Lead Sponsor:

Louis Bherer

Collaborating Sponsors:

Canadian Institutes of Health Research (CIHR)

The Montreal Health Innovations Coordinating Center (MHICC)

Conditions:

Aging

Cardiovascular Risk Factor

Eligibility:

All Genders

60+ years

Phase:

NA

Brief Summary

The ACTIONcardioRisk trial is designed to investigate the effect of aerobic and progressive resistance training exercises combined with cognitive training, on neurocognitive functioning of sedentary o...

Detailed Description

The proportion of older adults is on the rise in Canada, with the fastest growth recorded among those seventy years of age or older. The prevalence of cardiovascular risk factors (CVRF) such as diabet...

Eligibility Criteria

Inclusion Criteria:

  • Adult aged 60 and older,
  • Normal or corrected vision and normal hearing for their age range,
  • No cognitive impairment (Mini-Mental State Examination - MMSE ≥ 25),
  • Inactive (< 150 min of physical activity per week).

Exclusion Criteria:

  • MMSE ≤ 24 or diagnosis of dementia,
  • Uncontrolled psychological / psychiatric condition within the past 6 months,
  • Neurological disease,
  • Severe exercise intolerance,
  • Respiratory disease (e.g., asthma, COPD),
  • Excessive alcohol consumption (> 15 drinks/week),
  • Documented cerebral, peripheral or coronary atherosclerotic disease,
  • Chronic systolic or diastolic heart failure,
  • Symptomatic aortic stenosis,
  • Atrial fibrillation,
  • Automatic implantable defibrillator or permanent pacemaker,
  • Malignant exertional arrhythmias,
  • Non-cardiopulmonary limitation to exercise (e.g., arthritis).

Key Trial Info

Start Date :

September 1 2021

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

December 31 2025

Estimated Enrollment :

159 Patients enrolled

Trial Details

Trial ID

NCT04962061

Start Date

September 1 2021

End Date

December 31 2025

Last Update

February 6 2025

Active Locations (1)

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1

Preventive medicine and physical activity centre (centre EPIC), Montreal Heart Institute

Montreal, Quebec, Canada, H1T1N6