Status:
UNKNOWN
Evaluation of The Efficacy of Triazavirin Versus Oseltamivir in Egyptian Patients Infected With COVID-19
Lead Sponsor:
Ain Shams University
Conditions:
Covid19
Eligibility:
All Genders
18-60 years
Phase:
PHASE4
Brief Summary
The aim of this study is to evaluate the efficacy and safety (side effects and / or adverse effects) of Triazavirin and Oseltamivir as treatment of Coronavirus Disease 2019 in Egyptian patients in mil...
Detailed Description
In December 2019, a series of pneumonia cases of unknown cause emerged, followed by a rapidly spread due to strong human-to-human transmission in china. Based on the clinical presentation, the pneumon...
Eligibility Criteria
Inclusion Criteria:
- Adults from 18 to 60 years old who signed informed consent;
- Laboratory confirmed SARS-CoV-2 infection by real-time RT-PCR.
- Chest computed tomography (CT) imaging-confirmed lung damage, including multiple small plaques and stromal changes in the lungs, which are obvious in the outer lung, or multiple ground-glass shadows and infiltration shadows in both lungs, although these changes might not be present in mild patients.
- Patients with history of fever (axillary temperature more than 37°С) or respiratory symptoms.
Exclusion Criteria:
- Patients who are unsuitable or who cannot participate safely in the study, as judged by the principal investigator (PI).
- Patients with serious liver disease (increase of liver transaminases enzymes).
- Patients with severe renal impairment (denoted by increase serum urea & serum creatinine) or continuous renal replacement therapy, hemodialysis, or peritoneal dialysis.
- Patients with severe anemia.
- Women with a positive pregnancy test, ongoing pregnancy, or who are breastfeeding.
- Patients with a history of allergy to medications or its metabolic components.
- Patients who have not signed informed consent.
- Patients participating in other clinical trials for COVID-19 within 30 days prior to screening.
- Patients participating in other clinical research in the past three months.
Key Trial Info
Start Date :
August 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2021
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04973462
Start Date
August 1 2021
End Date
December 30 2021
Last Update
July 22 2021
Active Locations (1)
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1
Fever Hospital of the Egyptian Armed Forces
Cairo, Egypt, 012345