Status:

UNKNOWN

Evaluation of The Efficacy of Triazavirin Versus Oseltamivir in Egyptian Patients Infected With COVID-19

Lead Sponsor:

Ain Shams University

Conditions:

Covid19

Eligibility:

All Genders

18-60 years

Phase:

PHASE4

Brief Summary

The aim of this study is to evaluate the efficacy and safety (side effects and / or adverse effects) of Triazavirin and Oseltamivir as treatment of Coronavirus Disease 2019 in Egyptian patients in mil...

Detailed Description

In December 2019, a series of pneumonia cases of unknown cause emerged, followed by a rapidly spread due to strong human-to-human transmission in china. Based on the clinical presentation, the pneumon...

Eligibility Criteria

Inclusion Criteria:

  1. Adults from 18 to 60 years old who signed informed consent;
  2. Laboratory confirmed SARS-CoV-2 infection by real-time RT-PCR.
  3. Chest computed tomography (CT) imaging-confirmed lung damage, including multiple small plaques and stromal changes in the lungs, which are obvious in the outer lung, or multiple ground-glass shadows and infiltration shadows in both lungs, although these changes might not be present in mild patients.
  4. Patients with history of fever (axillary temperature more than 37°С) or respiratory symptoms.

Exclusion Criteria:

  1. Patients who are unsuitable or who cannot participate safely in the study, as judged by the principal investigator (PI).
  2. Patients with serious liver disease (increase of liver transaminases enzymes).
  3. Patients with severe renal impairment (denoted by increase serum urea & serum creatinine) or continuous renal replacement therapy, hemodialysis, or peritoneal dialysis.
  4. Patients with severe anemia.
  5. Women with a positive pregnancy test, ongoing pregnancy, or who are breastfeeding.
  6. Patients with a history of allergy to medications or its metabolic components.
  7. Patients who have not signed informed consent.
  8. Patients participating in other clinical trials for COVID-19 within 30 days prior to screening.
  9. Patients participating in other clinical research in the past three months.

Key Trial Info

Start Date :

August 1 2021

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

December 30 2021

Estimated Enrollment :

80 Patients enrolled

Trial Details

Trial ID

NCT04973462

Start Date

August 1 2021

End Date

December 30 2021

Last Update

July 22 2021

Active Locations (1)

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1

Fever Hospital of the Egyptian Armed Forces

Cairo, Egypt, 012345