Status:

RECRUITING

An Observational Study of Carbaglu® for the Treatment of MMA and PA in Adults and Pediatrics

Lead Sponsor:

RECORDATI GROUP

Collaborating Sponsors:

Target PharmaSolutions, Inc.

Conditions:

Hyperammonemia

Methylmalonic Acidemia

Eligibility:

All Genders

Brief Summary

To obtain short-term and long-term clinical safety information, in pediatric and adult patients with PA and MMA treated with Carbaglu®.

Detailed Description

This study is being conducted to obtain short-term and long-term clinical safety information from adult and pediatric patients treated for hyperammonemia due to Methylmalonic Acidemia (MMA) and Propio...

Eligibility Criteria

Inclusion Criteria:

  1. Provision of signed and dated informed consent/assent form

  2. Prescribed and treated with Carbaglu®

  3. Have an established diagnosis of PA or MMA defined as follows:

    • Diagnosed with PA by semi quantitative urine organic acid analysis, defined as presence of elevated methylcitric acid and normal methylmalonic acid levels and no evidence of biotin related disorders in the organic acid analysis; OR
    • Diagnosed with MMA by semi quantitative urine organic acid analysis, defined as elevation of methylmalonic acid and no evidence of vitamin B12 dependent disorder on plasma amino acid analysis (vitamin B12 dependency is defined by documented vitamin B12 responsiveness).

AND/OR

  • Confirmation by molecular genetic testing

Exclusion Criteria:

  • None

Key Trial Info

Start Date :

June 30 2022

Trial Type :

OBSERVATIONAL

Allocation :

ESTIMATED

End Date :

June 30 2032

Estimated Enrollment :

20 Patients enrolled

Trial Details

Trial ID

NCT05040178

Start Date

June 30 2022

End Date

June 30 2032

Last Update

April 15 2025

Active Locations (5)

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Page 1 of 2 (5 locations)

1

Children's National Hospital

Washington D.C., District of Columbia, United States, 20010

2

University of South Florida

Tampa, Florida, United States, 33606

3

Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, United States, 60611

4

Riley Children's Hospital

Indianapolis, Indiana, United States, 46202

An Observational Study of Carbaglu® for the Treatment of MMA and PA in Adults and Pediatrics | DecenTrialz