Inclusion Criteria:

• Patient over 18 years old, and less than 85 years old.
• Patient with positive AAN (AAN ≥ 1/160) with the following specificity: anti-Scl70 or anti-centromere or anti-RNApolIII, or any other auto-antibodies related to systemic sclerosis
• Patient with RP reported by the subject and confirmed by the physician.
• Patient affiliated to a health insurance system.
• Patient who accepts to participate to the study and signs an inform consent form.

Exclusion Criteria:

• Patient with an SSc diagnosis according to ACR/EULAR 2013 criteria.
• Patient with skin fibrosis at screening.
• Patient with antiplatelet treatment at screening.
• Patient with contraindications to clopidogrel.
• Patient treated by immunosuppressive agent at screening.
• Patient treated by anticoagulants at screening
• Pregnant or breastfeeding women.
• Women of childbearing age refusing effective contraception method during the study treatment (24 months).
• Incompetent adults (i.e. Individuals under the protection of a conservator)