Status:
RECRUITING
Association Between Plasma Level of Mannose Binding Lectin and Human Reproduction
Lead Sponsor:
Aalborg University Hospital
Conditions:
Mannose-Binding Lectin Deficiency
Recurrent Pregnancy Loss
Eligibility:
FEMALE
18-41 years
Brief Summary
A low plasma level of mannose binding lectin (p-MBL) is associated with unexplained recurrent pregnancy loss (RPL), but it is not investigated if it is associated with unexplained reproductive failure...
Detailed Description
The prevalence of a low p-MBL level is higher in patients with unexplained RPL than in the background population, while a high level is significantly less frequent in RPL patients (Nørgaard-Pedersen e...
Eligibility Criteria
Inclusion Criteria:
fulfil one of the following:
- 3 consecutive pregnancy losses after spontaneous conception
- 3 consecutive pregnancy losses after assisted reproductive technology treatment (ART) including IVF, ICSI and FET
- 3 failed embryo transfers characterized by no achieved pregnancy (after 3 cycles with minimum 1 embryo transfer of a good-quality embryo in each cycle.)
Exclusion Criteria:
- Age <18 or >45 years
- AMH <4.0 pmol/l unless donor egg in previous cycles
- Significant uterine malformation
- Known endometrial pathologies including intrauterine endometriosis, adenomyosis, hyperplasia or polyps
- Known chromosomal abnormalities
- Pregnancy >9 weeks of gestation at the time collecting the blood sample
Key Trial Info
Start Date :
January 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 30 2026
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT05169541
Start Date
January 1 2016
End Date
November 30 2026
Last Update
November 24 2025
Active Locations (1)
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1
Aagaard Klinik
Aarhus, Denmark, 8200