Status:
UNKNOWN
IL6&8 in Malnourished Children With Acute Diarrhea
Lead Sponsor:
Sohag University
Conditions:
Acute Diarrhea
Severe Acute Malnutrition
Eligibility:
All Genders
6-5 years
Brief Summary
Cytokines, such as IL-6 and IL-8 can be used as markers of acute infections, including acute gastroenteritis. However, there have been no previous studies on the levels of IL-6 and IL-8 in malnourishe...
Detailed Description
Acute gastroenteritis remains a common health problem among children worldwide with significant morbidity, mortality, and economic burden. Diarrheal diseases account for more than half-million deaths ...
Eligibility Criteria
Inclusion
- Group 1: Cases (Malnourished children with acute diarrhea)
- Age: 6 months to 5 years.
- Severe acute malnutrition. Infants and children who are 6-59 months of age and have a mid-upper arm circumference \< 115 mm or a weight for height/length \<-3 Z-score of the WHO growth standards or have bilateral edema.
- Acute diarrhea: Defined according to WHO criteria as the "passage of loose or watery stools at least three times in a 24 h period", lasts less than 14 days, with or without fever or vomiting, but considering the importance of change in stool consistency rather than frequency, and the usefulness of parental insight in deciding whether children have diarrhea or not.
Exclusion
- History of antibiotic therapy in the last 72 hours.
- Acute diarrhea in association with systemic infections
- Malignancy
- Chronic diarrhea
- Autoimmune and autoinflammatory diseases.
- Chronic renal/liver failure
- Diabetes mellitus
- Group 2: Control (Non-malnourished children with acute diarrhea)
- Inclusion Criteria:
- Healthy children aged 6 months to 5 years.
- Acute diarrhea
Key Trial Info
Start Date :
January 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2023
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05183789
Start Date
January 1 2022
End Date
January 1 2023
Last Update
September 21 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Sohag University Hospital
Sohag, Egypt, 82524