Status:
UNKNOWN
Effects of Intermittent Versus Continuous Energy Restriction on Metabolic Adaptation in Women With Obesity
Lead Sponsor:
Universidade do Porto
Collaborating Sponsors:
University of Lisbon
Conditions:
Obesity
Weight Loss
Eligibility:
FEMALE
20-45 years
Phase:
NA
Brief Summary
One of the major challenges for treating obesity is to maintain a weight reduced state on the long term due to the high rate of weight regain. Therefore, the aim of this study is to evaluate the effec...
Detailed Description
Literature is full of lifestyle interventions aimed for weight loss (WL) in several populations. However, one of the major challenges for treating obesity is WL maintenance on the long term due to the...
Eligibility Criteria
Inclusion
- Women
- BMI ranging between 30 and 39.9 kg/m2
- Age between 20-45 years
- Weight stable in the last 6 months (less than 5% weigh variation)
- Inactive (less then 150 min/week of moderate physical activity or 75 min/week of vigorous physical activity
- Living in Lisbon Metropolitan Area and being able to drive to Faculty of Human Kinetics and Germano de Sousa Laboratory (Algés)
- Available to be randomized to any of the trial groups (CER or IER)
- Willing to commit with the assigned group protocol, including the nutritional intervention and lifestyle recommendations, as well as being available for participation in all evaluation moments.
Exclusion
- Previous or present health disorders: cancer, autoimmune, cardiac, psychiatric, kidney and liver disease (except liver steatosis), diabetes, chronic intestinal inflammatory disease, or other medical conditions known to affect energy balance homeostasis
- Menopause
- Hormonal or thyroid disorder
- Medications that promote weight gain or alter energy balance, including corticosteroids, antidepressants, anxiolytics, mood-stabilizing, and antipsychotics
- Medications or dietary supplements for weight-loss in the past 3 months
- Pregnant for the past 6 months or breastfeeding
- Planning to get pregnant in the next 2 years or getting pregnant during the study
- Current consumption of more than 14 alcoholic drinks per week or other substance abuse, and/or current acute treatment or rehabilitation program for alcohol/substance abuse
- Surgery or in hospital admission for the last month
- Positive for Covid-19 in the past 3 months or testing positive during the intervention phase of the study
Key Trial Info
Start Date :
January 13 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2024
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT05184361
Start Date
January 13 2022
End Date
June 1 2024
Last Update
January 3 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Faculdade de Motricidade Humana da Universidade de Lisboa
Cruz Quebrada, Lisbon District, Portugal, 1495-751