Status:
RECRUITING
Sleep and Circadian Mechanisms in Hypertension
Lead Sponsor:
Oregon Health and Science University
Conditions:
Hypertension
Cardiovascular Diseases
Eligibility:
All Genders
25-64 years
Phase:
NA
Brief Summary
This study is a mechanistic clinical trial designed to investigate the effects of the circadian system and sleep on non-dipping blood pressure (BP) in people with hypertension (HTN).
Detailed Description
This study is a mechanistic clinical trial designed to study the effects of the circadian system and sleep on non-dipping blood pressure (BP) in people with hypertension (HTN). Investigators will stud...
Eligibility Criteria
Inclusion
- Ages 25-64
- BMI 18.5-42kg/m2
- Hypertension (average resting blood pressure between 130/80 mmHg and 160/100 mmHg)
Exclusion
- Over 5 pack-years of smoking;
- Prior shift work within 12 months prior to the study;
- Travel greater than three time zones for at least 3 months;
- History of heart failure, cardiomyopathy, or history of bypass surgery, angioplasty, or previous myocardial infarction;
- Acute or chronic diseases (except hypertension) that may affect outcome measures;
- History of psychological conditions;
- Sleep disorders, like severe sleep apnea, insomnia, etc.;
- Prescription medications (Contraceptives and anti-hypertensive medications are permissible);
- History of Illicit drug use and alcohol dependency;
- 30 days free of cannabis use prior to the study;
- Pregnancy;
- Upper cut-off of 160/100 mmHg for BP
Key Trial Info
Start Date :
August 4 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 30 2028
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT05184933
Start Date
August 4 2022
End Date
March 30 2028
Last Update
March 21 2025
Active Locations (1)
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1
Oregon Health and Science University
Portland, Oregon, United States, 97239