Status:
COMPLETED
Comparison of the Genotoxicity of Desflurane and Propofol
Lead Sponsor:
Muğla Sıtkı Koçman University
Conditions:
DNA Damage
Anesthesia
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate if the anesthetics propofol and desflurane can damage DNA according to comet essay in patients submitted to lumbar disc surgery.
Detailed Description
It is expected that DNA damage information provide the possible genotoxic effects of inhalational and intravenous anesthetics and contribute to the establishment of strategies aimed at reducing the ri...
Eligibility Criteria
Inclusion
- Ability to understand and willingness to sign an informed consent form
- Elective lumbar spinal surgery that will take at least 120 minutes,
- American Society of Anesthesiologists (ASA) physical status I and II
Exclusion
- Patients with ASA physical status III or IV disease
- Chronic systemic disease (diabetes mellitus,chronic pulmonary disorders, chronic kidney and liver disorders)
- Smoking or alcohol consumption
- Recently received radiation, chemotherapy
- Malignancy
- Patients who will receive blood transfusion during the operation
- Users of antioxidant supplements
- Patients who have received general anesthesia in the last three months
- Patients with known occupational exposures (operating room personnel, chemical plant worker
Key Trial Info
Start Date :
January 17 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 20 2022
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05185167
Start Date
January 17 2022
End Date
March 20 2022
Last Update
March 31 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Mugla Sitki Kocman University
Muğla, Turkey (Türkiye), 48000