Status:
COMPLETED
Active Gains in Brain Using Exercise During Aging
Lead Sponsor:
Universidad de Granada
Collaborating Sponsors:
Instituto Mixto Universitario Deporte y Salud (iMUDS)
Centro de Investigación Mente, Cerebro y Comportamiento (CIMCYC)
Conditions:
Healthy
Cognitive Function 1, Social
Eligibility:
All Genders
65-80 years
Phase:
NA
Brief Summary
AGUEDA (Active Gains in brain using Exercise During Aging) is a randomized controlled trial designed to examine the effects of a 24-week resistance exercise program on brain health in cognitively norm...
Detailed Description
Exercise has emerged as the most promising non-pharmacologic intervention for improving brain health in older adults. The main aim of AGUEDA (Active Gains in brain using Exercise During Aging) trial i...
Eligibility Criteria
Inclusion
- Men and women 65 - 80 years.
- Able to speak and read fluent Spanish.
- Living in community during the study.
- Reliable means of transportation.
- Being physical inactive (i.e., not to be participating in the last 6 months in any resistance exercise program, or accumulating less than 600 METS/Week of moderate-vigorous physical activity).
- Classified as cognitively normal according to Stics-m MMSE and MOCA tests.
Exclusion
- Ambulatory with pain or regular use of an assisted walking device.
- Medical contraindication for inclusion in an exercise program.
- Neurological condition (Multiple Sclerosis, Parkinson Disease, Dementia) or brain injury (traumatic or stroke).
- Current diagnosis and treatment of a DSM-V Axis I or II disorder including major depression and seeing a psychologist, therapist, or psychiatrist.
- History of major psychiatric illness including schizophrenia, general anxiety disorder or depression (GDS-30\>=15).
- Current treatment for congestive heart failure, angina, uncontrolled arrhythmia, deep venous thrombosis or other cardiovascular event.
- Myocardial infarction, coronary artery bypass grafting, angioplasty or other cardiac condition in the past year.
- Current or previous treatment for any type of cancer.
- Type I Diabetes or uncontrolled Type II Diabetes defined as Insulin dependent or Hba1C greater than 10.
- Recent treatment for alcohol or substance abuse.
- Presence of metal implants (e.g., pacemaker, stents, joint replacement) that would be MRI ineligible.
- Claustrophobia.
- Color blindness.
- Diagnosis of COVID-19 with hospitalization in intensive care unit.
- Any other consideration that interferes with the study aims and could be a risk to the participant, at the discretion of the researcher.
Key Trial Info
Start Date :
January 2 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 11 2022
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT05186090
Start Date
January 2 2021
End Date
December 11 2022
Last Update
March 19 2024
Active Locations (1)
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1
University of Granada
Granada, Andalusia, Spain, 18016