Status:
RECRUITING
Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Collaborating Sponsors:
ZonMw: The Netherlands Organisation for Health Research and Development
Conditions:
Mechanical Ventilation
Fluid Overload
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Timely recognition and treatment of fluid overload can expedite liberation from invasive mechanical ventilation in intensive care unit (ICU) patients. Lung ultrasound (LUS) is an easy to learn, safe, ...
Detailed Description
Objective: The aim of this study is to assess the effect of LUS-guided deresuscitation on duration of invasive ventilation in ICU patients. Hypothesis: LUS-guided fluid deresuscitation is superior ...
Eligibility Criteria
Inclusion
- Admission to one of the participating ICUs;
- Invasively ventilated for less than 24 hours at randomization;
- Expected to be under invasive ventilation for longer than 24 hours after randomization.
Exclusion
- Age below 18 years old;
- Suspected or confirmed pregnancy;
- Participation in other interventional trials with similar endpoints;
- Use of long term home mechanical ventilation;
- Neurological condition that can prolong duration of mechanical ventilation (i.e.Guillain-Barré syndrome, high spinal cord lesion, amyotrophic lateral sclerosis, multiple sclerosis, or myasthenia gravis);
- Conditions in which LUS cannot be performed or correctly interpreted (i.e. chest wall abnormalities, morbid obesity, and pre-existing interstitial lung disease);
- Conditions in which targeting a negative fluid balance is discouraged (i.e. subarachnoid bleeding, severe rhabdomyolysis (CK \> 20.000);
- Previous participation in this RCT;
- Patients transferred from another center and invasively ventilated for longer than 24 hours.
Key Trial Info
Start Date :
December 22 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT05188092
Start Date
December 22 2021
End Date
June 1 2026
Last Update
December 5 2025
Active Locations (3)
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1
Rijnstate
Arnhem, Gelderland, Netherlands, 6800 TA
2
Amsterdam UMC, location VUMC
Amsterdam, North Holland, Netherlands, 1081 HV
3
Amsterdam UMC, location AMC
Amsterdam, North Holland, Netherlands, 1105AZ