Status:
ACTIVE_NOT_RECRUITING
Taxifolin/ergothioneine and Immune Biomarkers in Healthy Volunteers (TaxEr)
Lead Sponsor:
University of Southampton
Collaborating Sponsors:
Blue California
Conditions:
Antioxidative Stress
Cold
Eligibility:
All Genders
50-65 years
Phase:
NA
Brief Summary
The complexities of the immune system make measuring the impact of dietary interventions upon its function challenging. The immune system is highly responsive to environmental influences, including th...
Detailed Description
Expert guidance is available to inform the design of human nutrition trials to ensure they include the most relevant immunological outcomes (Albers, 2013). In this study, ex vivo phagocytosis and oxid...
Eligibility Criteria
Inclusion
- age 50-65yr
- BMI 18.5-30kg/m2
- Willing to avoid consumption of foods rich in Taxifolin/DHQ and Ergothioneine during the study period
- Willing to avoid taking any other food supplements or high doses of vitamins during the study period
- Able to provide written informed consent.
Exclusion
- Use of prescription medication which may influence immune function, such as anti-inflammatory or immunosuppressant medication
- Diabetes requiring any medication
- Liver cirrhosis
- A history of drug or alcohol misuse
- Asplenia or other acquired or congenital immunodeficiencies
- Any autoimmune disease including connective tissue diseases
- Malignancy
- Laboratory confirmed SARS-CoV-2 infection within last 3 months
- self-reported symptoms of acute or recent infection (including use of antibiotics within the last 3 months)
Key Trial Info
Start Date :
November 10 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2025
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT05190432
Start Date
November 10 2021
End Date
July 1 2025
Last Update
April 1 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
NIHR Southampton Biomedical Research Centre
Southampton, Hampshire, United Kingdom, SO16 6YD