Status:
RECRUITING
Effect of Theta-Burst Transcranial Magnetic Stimulation (TBS) for Freezing of Gait
Lead Sponsor:
Anhui Medical University
Conditions:
Transcranial Magnetic Stimulation
Freezing of Gait
Eligibility:
All Genders
40-85 years
Phase:
NA
Brief Summary
To investigate the treatment effect of Theta-burst Transcranial Magnetic Stimulation (TBS) on patients with freezing of gait (FOG) and the underlying neural mechanism.
Detailed Description
This was a open-label clinical trial to assess the efficacy and underlying neural mechanism of TBS among patients with FOG. Forty patients with FOG were treated with TBS for 1 week. Before the TBS tr...
Eligibility Criteria
Inclusion
- diagnosis of FOG with expertise in movement disorders.
- the score of item 3 of the FOG questionnaire ≥1.
- ongoing treatment with a stable dose of any medication for 2 months.
- 40 years of age or older.
Exclusion
- a history of addiction, psychiatric disorders, or neurological diseases other than PD.
- focal brain lesions on T1-/T2-weighted fluid-attenuated inversion recovery images.
- anti-PD medication adjustments during rTMS treatment.
- history of substance abuse within the past 6 months.
- nonremovable metal objects in or around the head.
- previously received rTMS treatment.
- prior history of seizure or history in first-degree relatives.
Key Trial Info
Start Date :
November 22 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2028
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05192759
Start Date
November 22 2021
End Date
December 30 2028
Last Update
November 19 2025
Active Locations (1)
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1
Cognitive Neuropsychology Lab Anhui Medical University
Hefei, Anhui, China, 230032