Status:
RECRUITING
TDCS to Improve Post-Stroke Cognitive Impairment
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
University of Maryland, College Park
National Institutes of Health (NIH)
Conditions:
Stroke
Stroke Sequelae
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
The investigators will conduct a randomized, double-blinded, sham-controlled trial of approximately 60 patients with minor stroke and post-stroke mild cognitive impairment (psMCI). Participants will b...
Detailed Description
Vascular cognitive impairment, ranging from vascular mild cognitive impairment to vascular dementia, is a leading cause of progressive cognitive dysfunction second only to Alzheimer Disease. While the...
Eligibility Criteria
Inclusion
- Adults (≥18 years) presenting with neurological symptoms due to acute ischemic stroke (symptom onset within the week prior to admission).
- Evidence on brain MRI of acute ischemic stroke (imaging negative strokes and TIAs will be excluded).
- Native English speaker (by self-report) prior to stroke.
- NIHSS \<8 at initial follow-up visit (approximately 30 days post-stroke).
- mRS 0-2 at initial follow-up visit.
Exclusion
- Primary intracerebral hemorrhage- as evidenced by blood on head CT or MRI.
- Presence of proximal large vessel occlusion.
- Cortical exam findings including aphasia or neglect.
- Prior report or history of dementia or undertreated psychiatric illness.
- Uncorrected hearing or visual loss.
- Inability to attend treatment or follow-up sessions.
- Inability to travel to College Park (UMD) for MEG recording sessions.
- Presence of any of the following that would lead to significant artifact on MEG: cardiac pacemaker, intracranial clips, metal implants or external clips within 10mm of the head, metal implants in the eyes (unlikely given that all patients will have an MRI and criteria are similar).
- Claustrophobia, obesity, and/or any other reason leading to difficulty staying in the MEG machine for up to 1 hour.
Key Trial Info
Start Date :
September 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2027
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05195398
Start Date
September 1 2022
End Date
August 31 2027
Last Update
September 16 2025
Active Locations (1)
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1
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States, 21224