Status:
UNKNOWN
Mapping the Human Colon Using Single Cell Sequencing
Lead Sponsor:
Bispebjerg Hospital
Collaborating Sponsors:
The Novo Nordisk Foundation Center for Basic Metabolic Research
Conditions:
Diabetes
Large Bowel Cancer
Eligibility:
All Genders
18+ years
Brief Summary
The overall purpose of this study is to describe the cellular composition of the human colon and its gene expression using scRNAseq and scATACseq methods. This will potentially provide is with a detai...
Detailed Description
The human colon is composed of four distinct histological layers: Serosa, muscularis externa, submucosa, and mucosa. The inner mucosal surface is composed of columnar epithelium and glandular tissue c...
Eligibility Criteria
Inclusion
- Patients referred for out-patient colonoscopy as a result of positive hemoccult.
- Patients able to read and understand danish.
- Patients able to give informed consent.
- Patients of Scandinavian ethnicity.
Exclusion
- Previous large bowel resections
- Suspicion pre or intraoperatively of benign or malignant disease of the colon
- Known inflammatory bowel disease.
- Immuno-modulation treatment
- Chemotherapy.
- Daily smoking
- \> 21 weekly units of alcohol
- \< 18 years of age
Key Trial Info
Start Date :
July 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2024
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05195502
Start Date
July 1 2022
End Date
July 1 2024
Last Update
February 8 2023
Active Locations (1)
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1
Bispebjerg University Hospital
Copenhagen, Denmark, 2720